https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31299 Wed 23 Feb 2022 16:01:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20455 Wed 11 Apr 2018 16:49:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26931 Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.]]> Wed 11 Apr 2018 14:54:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19404 Wed 11 Apr 2018 13:19:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19242 Wed 11 Apr 2018 12:53:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16805 Wed 11 Apr 2018 11:29:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9196 Wed 11 Apr 2018 10:54:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15178 Tue 11 Dec 2018 16:37:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13590 Sat 24 Mar 2018 10:35:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20838 Sat 24 Mar 2018 08:05:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19159 Sat 24 Mar 2018 07:52:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19310 Sat 24 Mar 2018 07:52:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23414 Euphorbia tirucalli (E. tirucalli) has been linked with various health benefits. This study aimed to optimize ultrasonic extraction conditions for euphol from E. tirucalli leaf. Different solvents were tested to determine the most effective solvent for extraction of euphol. Then, response surface methodology (RSM) was employed to optimize ultrasound-assisted extraction conditions including temperature, time and power for maximal extraction of euphol. Our results showed that ethyl acetate:ethanol (4:1, v/v) was the most effective solvent for the extraction of euphol. Ultrasonic temperature and time had a positive impact, whereas, ultrasonic power had a negative effect on the extraction efficiency of euphol. The optimum ultrasonic extraction conditions for euphol were identified as: solvent-to-fresh sample ratio of 100:32 mL/g; ultrasonic temperature of 60 °C; ultrasonic time of 75 min and ultrasonic power of 60% (150 W). Under these optimum conditions, approximately 4.06 mg of euphol could be obtained from one gram of fresh E. tirucalli leaf. This extract also contained phenolic compounds (2.5 mg GAE/g FW) and possessed potent antioxidant capacity. These optimal conditions are applicable for a larger scale to extract and isolate euphol for potential utilization in the pharmaceutical industry. Keywords]]> Sat 24 Mar 2018 07:13:54 AEDT ]]>